Behavioral Variant Frontotemporal Dementia: Diagnosis and Treatment Interventions

Abstract Purpose of Review The diagnosis and treatment behavioral variant frontotemporal dementia is challenging often delayed because overlapping symptoms with more common syndromes or primary psychiatric illnesses. purpose this paper to explore the relevant presentation, diagnostic workup, pathophysiology, both pharmacologic non-pharmacologic management. Recent Findings Behavioral a highly heritable disorder. gradual accumulation diseased protein culminates in destruction those brain circuits responsible for much one’s emotional social functioning. Summary progressive neurodegenerative disorder far-reaching impact on patients caregivers. Patients present blunting, lack empathy, apathy, disinhibition. Non-pharmacologic interventions caregiver support are cornerstone treatment. use cholinesterase inhibitors memantine not supported by evidence. While current therapies target only certain symptoms, there disease modifying agents currently nearing clinical research stage.